Noninvasive Study of Portal Hypertension and Hepatic Interstitial Pressure With Advanced MRE

Overview

About this study

The purpose of this study is to evaluate the accuracy of 3D vector MRE in predicting hepatic venous pressure gradient (HVPG) and validate its potential to substitute surveillance EGD (“virtual EGD” with risk probabilities output).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Primary liver diseases.
Diagnosis of suspected portal hypertension with clinically-indicated EGD exam.
Chronic liver diseases with HVPG exam.
Age ≥ 18 years

Exclusion Criteria:

History of liver transplantation or hepatic resection
History of splenectomy.
Absolute contraindications to MRI, including pacemaker, AICD device, cochlear implant, VP shunt, aneurysm clip, a deep brain stimulator, and severe claustrophobia.
Women who are pregnant or breastfeeding.
Any severe medical condition that, in the opinion of the Principal Investigator, would serve as exclusion criteria for study enrollment.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 06/12/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Meng Yin, Ph.D.	Open for enrollment	Contact information: Megan Braski (507) 284-2638 Braski.Megan@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Meng Yin, Ph.D.

Open for enrollment

Contact information:

Megan Braski

(507) 284-2638

Braski.Megan@mayo.edu

More information

Publications

Publications are currently not available

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