Longitudinal Changes in Islet Function During Pregnancy

Overview

About this study

In this study we will study 120 pregnant women with a BMI >/= 25kg/m2.

The aim is to understand the changes that occur in endocrine pancreatic function during pregnancy. We are recruiting women with an elevated BMI as they will be at higher risk for GDM and following completion of the study we will be able to compare differences in glucose metabolism between those who did and did not develop GDM.

Patients will be identified and contacted by reviewing schedules in the OB clinic and through advertisement. We will only include individuals who have an ultrasound confirmed single pregnancy with no complications and no history of diabetes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subjects will be recruited 1 year from their most recent live birth.
30 with GDM in the preceding pregnancy.
30 with no history of GDM.

Exclusion Criteria:

Individuals < 20 or > 40 years at the preceding pregnancy.
Active systemic illness.
Preceding multiple gestation pregnancy.
Taking medication that affects glucose metabolism.
Upper GI surgery that alters gastric emptying.
Current BMI < 25kg/m^2.
For the GDM group, those with GDM in any pregnancy prior to the most recent pregnancy will be excluded (to reduce within group heterogeneity)
Currently pregnant or breastfeeding.

Eligibility last updated 4/13/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Aoife Egan, M.B., B.Ch., Ph.D.	Open for enrollment	Contact information: Aoife Egan M.B., B.Ch., Ph.D. (507) 284-4080 Egan.Aoife@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Aoife Egan, M.B., B.Ch., Ph.D.

Open for enrollment

Contact information:

Aoife Egan M.B., B.Ch., Ph.D.

(507) 284-4080

Egan.Aoife@mayo.edu

More information

Publications

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Clinical Trials