Clinical Trials

Inclusion Criteria:

Patients with acute PE will be eligible for participation in the study if:

• Acute PE < 24 hours from diagnosis.
• Signs of right heart strain:
  • Elevated troponin;
  • Elevated pro-BNP;
  • CT or echo evidence of right heart strain.

Exclusion Criteria:

Patients with PE will be excluded when:

• Age <18 years of age.
• Known pulmonary hypertension from another condition (other than PE).
• Pulmonary emboli only involve the subsegmental vessels.
• Hypotension (systolic blood pressure < 80mmHg) or requiring vasopressors.
• Cardiac pacemaker present.
• PE occurred despite adequate anticoagulation (acute on chronic PE).
• History of pulmonary valve repair/replacement.
• Status post systemic or catheter-directed thrombolytic therapy for acute PE.
• Pregnant.

Healthy control patients (without PE).

• All exclusion criteria above would apply to the control population as well. Consented, healthy controls, will have Eko stethoscope recordings at rest and after exertion. Subjects will be asked to ascend 1-4 flights of stairs, based on the judgment of the participant and their level of activity, to elevate respiratory and heart rates. Exercise will be supervised by study personnel (nurse or physician).

• Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

  Eligibility last updated 7/24/23. Questions regarding updates should be directed to the study team contact.