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Fecal Microbiome with Multiple System Atrophy

Overview

About this study

The purpose of stiudy is to assess whether the fecal microbiomes of patients with progressive MSA exhibit deviations in microbial species composition, proteins, or metabolites as compared to healthy clinical controls, environmental controls, and a Parkinson’s disease comparison group.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Aged 30-80 years.
  • Participants who are willing and able to give informed consent.
  • MSA patients fulfill Consensus Criteria for possible or probable MSA and diagnosed by a Mayo neurologist with MSA.
  • PD patients diagnosed with PD by a Mayo neurologist.
  • Healthy controls without evidence of neurologic disease or autonomic dysfunction.
  • Environmental controls residing in the same household as MSA and PD patients.

Exclusion Criteria:

  • Pregnant or breastfeeding women.
  • Participants with a clinically significant or unstable medical or surgical condition that, in the opinion of the investigator, might preclude safe completion of the study or might affect the results of the study.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/26/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wolfgang Singer, M.D.

Open for enrollment

Contact information:

Tonette Gehrking CAP

(507) 284-0336

adc.research@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20560326

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