Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
1. Male or female age 40 years or older
2. IPF Diagnosis:
1. Satisfying the 2022 American Thoracic Society/European Respiratory Society
/Japanese Respiratory Society/Latin American Thoracic Association
(ATS/ERS/JRS/ALAT) diagnostic criteria (Raghu 2022) confirmed by the investigator
2. UIP or probable UIP based on chest HRCT obtained within 2 months of Day 0, or
historical lung biopsy consistent with UIP.
3. If receiving antifibrotic agents pirfenidone or nintedanib, patients must be receiving
a stable dose for ≥ 2 months prior to Day 0 and planning to stay on stable background
therapy; if not receiving pirfenidone or nintedanib, patients must be naive to both
drugs or not have received either for at least 4 weeks prior to Day 0 and remain off
background therapy with no intention to start or re-start (combination of nintedanib
and pirfenidone not allowed).
4. If receiving monotherapy for the treatment of pulmonary hypertension (e.g.
phosphodiesterase 5 inhibitors, endothelin receptor antagonists or inhaled or oral
prostanoid therapy), patients must be receiving a stable dose for ≥ 4 weeks prior to
Day 0 and planning to remain on a stable dose throughout the study.
5. FVC ≥ 40% of predicted normal according to Global Lung Initiative (GLI)
6. Diffusion Capacity of Carbon Monoxide (DLCO) [corrected for hemoglobin] ≥ 25% to <80%
of predicted normal
Exclusion Criteria:
1. Relevant airways obstruction (pre-bronchodilator Forced Expiratory Volume in one
second to forced vital capacity ratio less than 70% (FEV1/FVC < 0.7))
2. In the opinion of the Investigator, other clinically significant pulmonary
abnormalities.
3. Known significant PAH, defined as previous clinical or echocardiographic evidence of
significant right heart failure, history of right heart catheterization showing a
cardiac index < 2 L/min/m^2, or PAH requiring combination of PAH-specific therapies or
any PAH parenteral therapy.
4. Emphysema ≥ 50% on HRCT assessed by the investigator, or the extent of emphysema is
greater than the extent of fibrosis according to reported results from the most recent
chest HRCT.
5. Acute IPF exacerbation within 6 weeks prior to screening and/or during the screening
period (investigator-determined).
6. ILD associated with other known causes
7. Lower respiratory tract infection requiring antibiotics within 4 weeks prior to Day 0
and/or during the screening period.
8. Major surgery (major according to the investigator's assessment) performed within six
weeks prior to Day 0 or planned during the course of the trial. (Being on a transplant
list is allowed).
9. AST or ALT > 1.5 x ULN, Bilirubin > 1.5 x ULN, Creatinine clearance < 30 mL/min
calculated by Cockcroft-Gault formula.
10. Underlying chronic liver disease (Child Pugh A, B or C hepatic impairment).
11. Cardiovascular diseases, any of the following:
1. Severe hypertension, uncontrolled despite treatment (≥ 160/100 mmHg)
2. Myocardial infarction within 6 months of Day 0
3. Unstable cardiac angina
12. Bleeding risk, any of the following:
a. Known genetic predisposition to bleeding;
b. Patients who require:
i. Fibrinolysis, full-dose therapeutic anticoagulation (e.g., vitamin K antagonists, direct thrombin
inhibitors, direct oral anticoagulants, heparin, hirudin)
ii. High dose antiplatelet therapy (> 325 mg/day of aspirin; > 75 mg/day ticlodipine or clopidogrel; any dose of
other 2b3a anti-platelet agents)
13. History of hemorrhagic central nervous system (CNS) event within 12 months of Day 0
14. Any of the following within 3 months of Day 0:
1. Hemoptysis or hematuria
2. Active gastro-intestinal (GI) bleeding needing hospitalization/intervention or
peptic ulcer disease
15. Coagulation parameters: International normalized ratio (INR) >2, prolongation of
prothrombin time (PT) and activated partial thromboplastin time (aPTT) by >1.5 x ULN
Note: Prophylactic low dose heparin or heparin flush as needed for maintenance of an
indwelling intravenous device (e.g. less than or equal to enoxaparin 40 mg s.c. per
day or heparin 5000 units s.c. every 8 hours), as well as prophylactic use of
antiplatelet therapy (e.g. acetyl salicylic acid (ASA) up to 325 mg/day, or
clopidogrel at 75 mg/day, or equivalent doses of other antiplatelet therapy) are not
prohibited.
16. History of thrombotic event (including stroke and transient ischemic attack) within 12
months of Day 0
17. Use of disease-modifying antirheumatic drugs, B-cell depleting therapies or
immunosuppressive medications, within 6 months of Day 0.
18. Use of systemic corticosteroids equivalent to prednisone >15mg/day within 2 weeks of
Day 0.
19. Simultaneous use of pirfenidone and nintedanib at screening.
20. Other disease that may interfere with testing procedures or in the judgment of the
Investigator may interfere with trial participation or may put the patient at risk
when participating in this trial.
21. Any documented active or suspected malignancy within 5 years prior to Day 0, except
appropriately treated basal cell carcinoma of the skin, in situ squamous cell
carcinoma of the skin or "under surveillance" prostate cancer.
22. Evidence of active infection (chronic or acute) based on clinical exam or laboratory
findings.
23. Any suicidal behavior in the past 2 years (i.e. actual attempt, interrupted attempt,
aborted attempt, or preparatory acts or behavior).
24. The patient has a confirmed infection with Severe Acute Respiratory Syndrome-
Coronvirus-2 (SARS-CoV-2) within the 4 weeks prior to Day 0 or during the screening
period.
25. Women who are pregnant, nursing, or who plan to become pregnant while in the trial.
26. Women of childbearing potential* not willing or able to use highly effective methods
of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per
year when used consistently for 28 days prior to and 3 months after IMP
administration.
27. In the opinion of the Investigator, active alcohol or drug abuse.
28. Patients not able to understand or follow trial procedures including completion of
self- administered questionnaires without help.
- A woman is considered of childbearing potential, i.e. fertile, following menarche
and until becoming post-menopausal unless permanently sterile. Permanent
sterilization methods include hysterectomy, bilateral salpingectomy and bilateral
oophorectomy
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 11/14/23. Questions regarding updates should be directed to the study team contact.