Find trials
Search tips

Ultrasound Imaging and Quantitative Vibro-Acoustic Assessment of Rickets Under the Age of Ten

Overview

About this study

The purpose of this study is to determine if ultrasound imaging of bone can identify the changes of impaired mineralization of the growth plates at the wrists and the knees, similar to those visible on plain radiographs.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Cases:  Prepubertal children less than 10 years of age with active nutritional or genetic rickets at enrollment (RSS  > 1.5 based on radiographs of the wrists and knees performed within 3 months prior to enrollment). Cases will be recruited from the Pediatric Endocrinology Bone Clinic or from the Mayo Clinic outpatient or inpatient services in Rochester, MN. Cases who return for follow-up and demonstrate improvement in RSS≥1.0 will be eligible for a single repeat ultrasound evaluation.
  • Controls:  Healthy children empaneled in Mayo Clinic primary care (Family Medicine or Community Pediatrics) matched for age (±3 mo), sex, and BMI (±0.5 kg/m^2).

Exclusion Criteria:

  • Known fracture at imaging site.
  • Rickets of prematurity.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 11/28/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Thomas Thacher, M.D.

Open for enrollment

Contact information:

Mary Johnson CCRP

(507) 293-7891

Johnson.Mary15@mayo.edu

More information

Publications

Publications are currently not available

More about research at Mayo Clinic

.
CLS-20566165

Mayo Clinic Footer