Multiple Imaging Evaluations of the Liver, Pancreas, and Fat

Overview

About this study

The purpose of this study is to develop multiparametric magnetic resonance elastography (MRE) imaging protocol to comprehensively characterize tissue microenvironment and microstructure along the liver-pancreas-adipose axis in a longitudinal study of 150 clinical NAFLD patients who had no diabetes (N=50), prediabetes (N=50), and diabetes (N=50). We expect to have 1-year follow-up examinations on at least 120 NAFLD patients assuming a 20% withdraw rate.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Primary liver diseases.
Diagnosis of NAFLD with 50 patients have no diabetes, 50 patients have prediabetes, and 50 patients have diabetes.
Age ≥ 18 years.

Exclusion Criteria:

History of liver transplantation or hepatic resection.
History of splenectomy.
Absolute contraindications to MRI, including pacemaker, AICD device, cochlear implant, VP shunt, aneurysm clip, a deep brain stimulator, and severe claustrophobia.
Women who are pregnant or breastfeeding.
Any severe medical condition that, in the opinion of the Principal Investigators, would serve as exclusion criteria for study enrollment.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/24/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Meng Yin, Ph.D.	Open for enrollment	Contact information: Jessica Olson (507) 266-3995 Olson.Jessica3@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Meng Yin, Ph.D.

Open for enrollment

Contact information:

Jessica Olson

(507) 266-3995

Olson.Jessica3@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials