Molecular Analysis to Drive Individualized Care in Lung Cancer

Overview

About this study

The purpose of this study is to determine if robotic biopsies provide sufficient material for whole genomics and transcriptomics, transcriptome anomalies are confined to tumor cells as opposed to background lung parenchyma, and whole genomics may provide further pathologic insight in cases where de novo primary may be difficult to discern from metastatic disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Subject age 18 years and older.
Subject is suitable for elective bronchoscopy.
Subject with a moderate to high risk of lung cancer based on clinical, demographic and radiologic information or with suspected metastatic disease.
Ability to provide blood or saliva sample.
Enrolled in study IRB#16-009655.
Ability to provide archived tissue.
Subject is able to understand and adhere to study requirements and able to provide informed consent.

Exclusion Criteria:

Individuals who have situations that would limit compliance with the study requirements.
Institutionalized (i.e., Federal Medical Prison).
Prior germline genetic testing with a 40+ multi-gene panel within the last 1 year of enrollment; AND/OR
Prior somatic tissue (250+ gene) testing within the prior 3 months of enrollment.
Of note: Women, who are pregnant, or planning to become pregnant, can take part in this study.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/12/24. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Janani Reisenauer, M.D.	Open for enrollment	Contact information: Cancer Center Clinical Trials Referral Office (855) 776-0015

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Janani Reisenauer, M.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information

Publications

Publications are currently not available

Clinical Trials