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Safety of 10°C Prolonged Lung Preservation Vs. Standard of Care

Overview

About this study

The purpose of this trial is to establish whether an organ preservation strategy maintaining donor lung at the temperature of 10°C for prolonged period of times (12-24hs) is safe and provide outcomes similar to the conventional preservation in ice cooler. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Donation after brain death (DBD) or donation after cardiac death (DCD).
  • Donor lungs are suitable to go straight to LTx (i.e., do not need ex vivo lung perfusion (EVLP) assessment).
  • 18-80 years old.
  • Primary lung transplantation.
  • Bilateral lung transplantation.

Exclusion Criteria:

  • Concerns with organ preservation technique.
  • Need for EVLP.
  • Re-transplantation.
  • Multi-organ transplantation (other organ in addition to lung).
  • Single Lung Transplantion.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/13/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sahar-Al-Sadat Saddoughi, M.D., Ph.D.

Open for enrollment

Contact information:

Jacqulyn Reiter

(507) 538-2224

Reiter.Jacqulyn@mayo.edu

More information

Publications

Publications are currently not available

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