Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing’s Disease

Overview

About this study

The purpose of this study is to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for lesion-specific surgical resection to impact clinical outcome. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Diagnosis of Cushing disease or required resection for non-corticotroph adenomas.
  • Agree to transsphenoidal resection.

Exclusion Criteria: 

  • Patients who are unable to consent (or if their legal guardian/representative decline to consent)
  • Patients who have known or suspected hypersensitivity to microbubble contrast agents or its components such as polyethylene glycol (PEG).

  • Patients who have hypersensitivity to perflutren.

For Non-Contrast Based Protocol:

Inclusion Criteria:

  • Patients undergoing any pituitary surgery with the study designated neurosurgeons.
  • Patients whose procedures require the use of an intra-operative BK ultrasound without contrast. 

Exclusion Criteria:

  • Patients who are unable to consent (or if their legal guardian/representative decline to consent)

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/22/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ian Mark, M.D., MSM

Open for enrollment

Contact information:

RST Neurologic Surgery Research Team

(507) 293-1963

More information

Publications

Publications are currently not available