Clinical Trials

Inclusion Criteria:

1. age ≥ 45 years;

2. diagnosis of hip fracture during working hours with a low-energy mechanism requiring
surgery;

3. troponin elevation on hospital arrival (at least one troponin level from hip fracture
occurrence to randomization above the upper limit of normal); and

4. written informed consent.

Exclusion Criteria:

1. taking a therapeutic dose of an anticoagulant for which no reversing agent is
available;

2. patients on a therapeutic vitamin K antagonist with a history of heparin induced
thrombocytopenia (HIT);

3. patients with peri-prosthetic fracture, open fracture or bilateral fractures;

4. patients requiring an emergency surgery for another reason (e.g., subdural hematoma);

5. patients with acute myocardial infarction with a mechanical complication (i.e., acute
papillary muscle rupture, ventricular septal defect), ST elevation myocardial
infarction, or cardiogenic shock;

6. patients refusing consent; or

7. patients previously enrolled in HIP ATTACK-2.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/5/24. Questions regarding updates should be directed to the study team contact.