Clinical Trials

Includsion Criteria:

• Research subject conditions that may result in alterations of ventilatory control (capnic status) and exercise capacity will be specifically reviewed as criteria for participation. \
• We will strive for a balanced male/female participant study population with between ages  18-40years.

Exclusion Criteria:

• Current pregnancy in women, alcohol use within the past 3 days prior to the experiment, history of balance problems (e.g. vertigo, neuropathy, central or peripheral vestibular disorders), recent cardiac problems or symptoms, and musculoskeletal disorders affecting the ability to perform a stress test in participants will lead to exclusion from participation.
• Patients currently taking carbonic anhydrase inhibitors, opioids, benzodiazepines, hypnotics, first-generation H1 antihistamines, amphetamines, and first-generation antipsychotics will also be excluded.
• Patients with a history of insomnia, sleep apnea, circadian rhythm disturbances, narcolepsy, movement disorders, chronic low blood pressure, fainting spells, multiple concussions, seizure disorders, migraines, severe headaches and panic attacks will also be excluded.
• If the patient took medications known to cause prolonged QTc interval and other cardiac arrhythmias, the researchers will exclude the patient from the study.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/13/2024. Questions regarding updates should be directed to the study team contact.