Clinical Trials

Inclusion Criteria: 

• Intention of female volunteers not to conceive for the period of study. 
• All women of childbearing potential will have a negative pregnancy test within 48 hours prior to any study because of the potential effect of pregnancy on glucose metabolism.

Exclusion Criteria:

• Age < 25 or > 65 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
• HbA1c ³ 6.5%.
• Use of any glucose-lowering agents including metformin or sulfonylureas.
• For female subjects: positive pregnancy test at the time of enrollment or study.
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/7/2024. Questions regarding updates should be directed to the study team contact.