Prostate Cancer Cell Lines Using Biopsies of Early Stage Prostate Cancer Patients and Research on Cancer Mechanisms Through Its Genes and Proteins

Overview

About this study

The purpose of this study aims to establish a total of 30 new primary prostate cancer cell lines using a portion of biopsy tissue from early-stage prostate cancer patients and to collect protein characterization data showing high expression for each cell line. The primary objective is to discover specific genes and proteins that show excessive expression differences in each group of prostate cancer cell lines. The specific genes and proteins obtained here will be used to find customized anticancer candidates for prostate cancer patients in the future. As a final objective, we aim to build a new classification of existing molecular subtypes of prostate cancer based on the existing prostate cancer subtypes of androgen receptor (AR) positive, neuroendocrine, ERG fusion positive and ERG fusion negative, and TP53 mutation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Early-stage prostate cancer patients.

Exclusion Criteria:

  • Prostate cancer patients with recurrent or metastatic disease or patients with benign tumors.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/25/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

SeungBaek Lee, Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Ryan Jacobson

Jacobson.Ryan1@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20574136

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