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ACVR1 Mutational Analysis in Individuals with Spine-associated Heterotopic Ossification

Overview

About this study

The purpose of this study is to conduct ACVR1 mutational analysis in individuals with heterotopic ossification of the spine.

 

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Individuals ≥ 18 years of age; and
  • Ossification of any of the paravertebral ligaments (anterior longitudinal ligament, posterior longitudinal ligament, ligamentum flavum, interspinous ligaments); with or without
  • Ossification of peripheral entheses; and/or
  • Extra-spinal HO

Exclusion Criteria: 

  • Gout
  • Rheumatoid arthritis
  • Paget’s disease of bone
  • Chrodrocalcinosis
  • Spondylosis deformans
  • Fibrodysplasia ossificans progressiva
  • Progressive osseous heteroplasia
  • Pregnant women

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/03/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Robert Pignolo, M.D., Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Robert Pignolo M.D., Ph.D.

(507) 284-5524

Pignolo.Robert@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20574437

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