Clinical Trials

Inclusion Criteria:

1. Aged ≥18 years

2. Solid renal mass consistent with RCC on either ultrasound, MRI, or CT

3. Longest tumor diameter measures 4.1-7cm

4. Tumor stage T1bN0M0 without vascular invasion, adenopathy, or distant metastatic
disease

5. For females of reproductive potential: use of highly effective contraception for at
least 1 month prior to enrollment and agreement to use such a method during study
participation

6. Provision of signed and dated informed consent form

7. Stated willingness to comply with all study procedures and availability for the
duration of the study

Exclusion Criteria:

1. Pregnancy

2. Severe renal insufficiency with an Estimated Glomerular Filtration Rate (eGFR) <30

3. Renal cell carcinoma as part of a syndrome

4. Horseshoe kidney

5. Patient unable to undergo renal mass protocol CT or MRI

6. Severe allergy to iodinated contrast not mitigated by steroid and diphenhydramine
prophylaxis

7. Uncorrectable coagulopathy, including a platelet count of <30,000/?L and/or an
international normalized ratio (INR) >2.5 that does not respond to platelet
transfusion or prothrombin complex concentrate infusion, respectively

8. Performance status precludes enrollment as determined by the investigators

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 1/27/23. Questions regarding updates should be directed to the study team contact.