Infections and Other Complications of Cirrhosis

Overview

About this study

The purpose of this study is to determine the current practice and outcomes in the following areas of hospitalized cirrhotic subjects: Community-acquired infections: determinants and outcomes, Nosocomial infections: determinants and outcomes, Development of second infections, Factors predicting ICU care, organ failure, death and disability, Patterns and adequacy of albumin use in infected and non-infected subjects, Quality-assurance and adequacy of management of complications of cirrhosis such as hepatic encephalopathy, variceal bleeding, hyponatremia and hypernatremia, Peri and post-liver transplant outcomes, regiional variations in outcomes and therapeutic strategies, and compare the ICU and 30 day course of patients with cirrhosis who get admitted to the ICU to those without cirrhosis in the ICU.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Age above 18 years
  • Cirrhosis as diagnosed by either liver histology or a combination of clinical, biochemical (low platelets, elevated bilirubin and/or INR, low albumin), radiologic (nodular liver on ultrasound) and endoscopic (esophageal varices) criteria.
  • Subject or surrogate able to provide consent for participation.

Exclusion Criteria

  • Subjects admitted for elective purposes

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/01/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Hugo Vargas, M.D.

Open for enrollment

Contact information:

Clinical Studies Unit

(904) 953-2255

More information

Publications

Publications are currently not available
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CLS-20577454

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