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Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty

Overview

About this study

The purpose of this study is to evaluate the impact of an extended oral TXA regimen on patient reported outcome scores, time to independent ambulation, postoperative range of motion, swelling, change in hemoglobin levels, 90-day complications, readmission and reoperation.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

    • Adults (age >18)
    • Written informed consent
    • Patients undergoing primary THA or TKA with a diagnosis of end-stage osteoarthritis
    • Patients receiving spinal anesthesia
    • Patients being discharged on postoperative day 1

Exclusion Criteria:

    • Patients with a TXA allergy
    • Patients undergoing revision procedures or partial knee arthroplasty
    • Patients undergoing primary THA or TKA for a diagnosis other than end-stage osteoarthritis
    • Patients receiving general anesthesia
    • Patients being discharged on the same day of surgery
    • Cancer patients
    • Patients with a history of prior VTE event
    • Patients on preoperative anticoagulants other than ASA

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/16/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Joshua Bingham, M.D.

Contact us for the latest status

Contact information:

Saad Tarabichi M.B., B.Ch.

(480) 342-4817

Tarabichi.Saad@mayo.edu

More information

Publications

Publications are currently not available

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