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Cell-Free Dna Epigenomics to Track the Dynamics of Organ Damage and Immune Exhaustion During Sepsis

Overview

About this study

The purpose of this study is to quantify cell-free DNA arising from organ-specific tissues and exhausted T cells in order to noninvasively track organ damage and immune dysfunction/exhaustion, respectively, during sepsis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients ≥ 18 years or older of age
  • Patients who’ve developed a shocked state (Hypotension or Lactate grade > 4) or Clinical Concern

Exclusion Criteria:

  • < 18 years of age
  • Pregnant Women
  • Nursing women
  • Women of childbearing potential who are unwilling to employ adequate contraception

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/30/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Aadel Chaudhuri, M.D., Ph.D.

Contact us for the latest status

Contact information:

Aadel Chaudhuri M.D., Ph.D.

(507) 293-2302

Chaudhuri.Aadel@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20577772

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