Validating Baseline Values in Patients With Possible Immune Checkpoint Inhibitor Myocarditis

Overview

About this study

The purpose of this study is to collect samples for hscTnT and hscTnI at baseline in those being started on ICIs who are identified by the clinicians treating these patients and then again subsequently when/if they develop myocarditis and are identified by the CardioOncology service.  The baseline samples will allow for analysis as to whether having an increased hscTn value at baseline is associated with a higher risk of myocarditis.  hscTnT is clinically necessary but hscTnI may not be. Then a proper assessment of the sensitivity, specificity, positive and negative predictive values of this testing will be accomplished.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients on immune checkpoint inhibitors who undergo troponin testing clinically.

Exclusion Criteria: 

  • Unable to speak English, unable to provide oral consent for themselves.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/3/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Allan Jaffe, M.D.

Contact us for the latest status

Contact information:

DLMP Research and Innovation Office

(507) 284-9080

DLMPRIO@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20578104

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