Efficacy of Selective Laser Trabeculoplasty Targeting Nasal Versus Inferior 180-degree

Overview

About this study

The purpose of this study to optimize SLT application when used in the management of open angle glaucoma (OAG).  

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18 years and older
  • Ability to comprehend the study procedures and agreement to proceed with primary SLT treatment
  • Diagnosis of primary or secondary open angle glaucoma or glaucoma suspects with ocular hypertension
  • Bilateral disease
  • Pre-SLT IOP >21 mmHg measured at least twice during patient’s lifetime with or without medication
  • Open angles with moderate to intense trabecular pigmentation
  • Mild to moderate visual field defects (24-2 standard mean deviations better than the Swedish interactive thresholding algorithm standard of 12 dB)
  • No adequate IOP control   (low treatment compliance, substantial adverse effects with eyedrops, and at least 2 IOP measurements higher than the individualized target IOP)

Exclusion Criteria: 

  • Unwilling or unable to give consent
  • Unable to attend scheduled post-operative visits
  • Previous history of either laser treatment or intraocular surgery, except for non-complicated cataract surgery (performed >6 months before SLT)
  • History of ocular trauma
  • Narrow angles
  • Retinal detachment
  • Active iris neovascularization or active proliferative retinopathy
  • Active uveitis
  • Monocular patients
  • Current use of steroids (ocular, periocular, or systemic)

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/14/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D., M.S.

Open for enrollment

Contact information:

Rami Darwich M.D., Ph.D.

Darwich.Rami@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20578332

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