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Autonomic Function after Multiple Sclerosis

Overview

About this study

This study aims to gain a better understanding of the autonomic responses of subjects with multiple sclerosis compared to healthy controls. Utilizing lab-based testing to induce well-characterized autonomic responses, the integrity of the autonomic nervous system through the spinal cord will be assessed though baseline catecholamine/glucocorticoid levels, recordings of sympathetic outflow, and spectral analysis of blood pressure and heart rate variability. Armed with these results, we will generate cardiovascular autonomic phenotypes for individuals to demonstrate normal and abnormal autonomic responses.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria

  • 18-50 years old.
  • Clinically confirmed diagnosis of multiple sclerosis  -OR- uninjured control.

Exclusion criteria

  • Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment).
  • Women who are pregnant or lactating.
  • Having a body mass index (BMI) ≥ 35 kg/m2.
  • Taking or being administered a medication known to potentially have adverse interactions with phenylephrine,
  • In the judgement of the principal investigator or clinical collaborator (Dr. Pittock), any illness or condition that will interfere with the patient’s ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/9/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ryan Solinsky, M.D.

Contact us for the latest status

Contact information:

Zachary Pohlkamp

(507) 422-0140

Pohlkamp.Zachary@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20578572

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