Mannitol-Based Solutions in the Quantification of Visceral Hypersensitivity

Overview

About this study

The purpose of this study is to assess the degree of GI dysfunction after (pain, nausea, diarrhea) utilizing visual analogue scales in patients undergoing CTEs for other causes vs. patients with known small bowel ulcerations/strictures (Crohn’s disease) with pain to develop normative and known abnormal values. Compare the degree of GI dysfunction in patients with DGBIs (Functional dyspepsia, irritable bowel syndrome, chronic abdominal pain) to patients undergoing CTEs for other causes and those with documented small bowel damage.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Patients >18 years of age undergoing CT enterography.
Willingness to participate in the study.
Capacity to provide informed consent.
Patient diagnosed with or suspected to have DGBI.
No evidence of organic, systemic, or metabolic disease (e.g. diabetes mellitus) to explain the symptoms on routine investigations.

Exclusion Criteria:

History of any bowel surgery.
Presence of documented pseudo-obstruction, diabetes mellitus with a hemoglobin A1c of more than or equal to 8, scleroderma, slow transit constipation and other diseases (structural or metabolic) which could interfere with interpretation of the study results.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/5/2024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Xiao Jing Wang, M.D.	Open for enrollment	Contact information: Riya Gupta (507) 422-5762 Gupta.Riya@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Xiao Jing Wang, M.D.

Open for enrollment

Contact information:

Riya Gupta

(507) 422-5762

Gupta.Riya@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials