Clinical Trials

Inclusion criteria:

• Resident of the United States (to make it possible to conduct future subject follow-up using the National Death Index)
• Age 18 years or older.
• Able to provide informed consent.
• Has a Mayo Clinic or affiliated Health Systems ID.

Exclusion criteria:

• Institutionalized (i.e., Federal Medical Prison)
• Individuals who do not comprehend English or Spanish (i.e., participants must be able to read and sign a consent form in English or Spanish without the assistance of an interpreter)
• Individuals who are unable to sign consent (e.g., mentally challenged, those declared legally incompetent).

Additional exclusion criteria for those undergoing tissue sampling (i.e., synovial biopsy, adipose tissue sampling):

1. Ongoing or suspected infection, acute or chronic, particularly local skin/soft tissue infection at potential biopsy sites
2. Ongoing antibiotic use
3. Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)
4. Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
5. Renal failure (serum creatinine > 1.5mg/dl)
6. Chronic active liver disease (AST>144 IU/L or ALT>165 IU/L)
7. Oral warfarin group medications or history of blood clotting disorders
8. Pregnancy or breastfeeding
9. Cancer on active treatment

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/27/2024. Questions regarding updates should be directed to the study team contact.