Magnetic Resonance Imaging, Cytometry, and Elastography Assessment of Liver Histopathology in Nonalcoholic Fatty Liver Disease

Overview

About this study

The purpose of this study is to assess the diagnostic performance of advanced multiparametric magnetic resonance imaging (MRI), magnetic resonance cytometry (MRC), and magnetic resonance elastography (MRE) approaches for integratively distinguishing steatosis, inflammation, ballooning, and fibrosis of the liver in 40 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Primary liver diseases.
Diagnosis of NAFLD.
Liver biopsy will be available within 90 days of the imaging exam
Age ≥ 18 years.

Exclusion Criteria:

History of liver transplantation or hepatic resection
Absolute contraindications to MRI, including pacemaker, AICD device, cochlear implant, VP shunt, aneurysm clip, a deep brain stimulator, and severe claustrophobia.
Women who are pregnant or breastfeeding.
Any severe medical condition that, in the opinion of the Principal Investigators, would serve as exclusion criteria for study enrollment.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 4/24/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location	Status	Contact
Rochester, Minn. Mayo Clinic principal investigator Meng Yin, Ph.D.	Open for enrollment	Contact information: Jessica Olson (507) 266-3995 Olson.Jessica3@mayo.edu

Mayo Clinic Location

Status

Contact

Rochester, Minn.

Mayo Clinic principal investigator

Meng Yin, Ph.D.

Open for enrollment

Contact information:

Jessica Olson

(507) 266-3995

Olson.Jessica3@mayo.edu

More information

Publications

Publications are currently not available

Clinical Trials