Clinical Trials

Inclusion Criteria:

• Patients with Hypertrophic Cardiomyopathy, Patients with Amyloid, Healthy Control Patients (all 18+).
• HCM Cases: ICD9 (425.1 or 425.11 or 425.18) OR ICD10 (I42.1 or I42.2) or HCM noted in medical history (from NLP text mining)
• No HCM Controls: Absence of any relevant ICD9 or ICD10 codes (or history of HCM) in any encounter, AND absence of HCM noted in medical history (from NLP text mining)
• Cardiac Amyloid Cases Inclusion: ICD9 (277.30 or 277.39) OR ICD10 (E85.4, E85.9 or E85.82) or cardiac amyloid noted in medical history (from NLP text mining)
• No Cardiac Amyloid Controls: Absence of relevant ICD9 or ICD10 code in any encounter, AND absence of any amyloid noted in medical history (from NLP text mining)

Exclusion Criteria: 

• HCM Cases: Age <18 yo
• No HCM Controls: Age <18 yo, family history of HCM, <2 health system encounters, clinical diagnosis of infiltrative cardiomyopathy
• Cardiac Amyloid Cases: Age < 18 yo, clinical diagnosis of other infiltrative cardiomyopathy
• No Cardiac Amyloid Controls Exclusion: Age < 18 yo, clinical diagnosis of other infiltrative cardiomyopathy, <2 health system encounters 

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/13/2025. Questions regarding updates should be directed to the study team contact.