Plasma Renin Concentrations in Cardiac Surgery

Overview

About this study

The purpose of this study is to measure renin concentrations before and after exposure to cardiopulmonary bypass and assess the impact of cardiopulmonary bypass on renin concentrations and assess relationship of renin concentrations with clinical outcomes in patients undergoing cardiac surgery.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult persons 18 years of age or greater.
  • Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass.

Exclusion Criteria:

  • Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device.
  • Emergency cardiac surgery.
  • Established diagnosis of any congenital heart disease.
  • End-stage kidney disease receiving kidney replacement therapy before surgery.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/03/2025. Questions regarding updates should be directed to the study team contact.
 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Patrick Wieruszewski, Pharm.D., R.Ph.

Contact us for the latest status

Contact information:

Patrick Wieruszewski Pharm.D., R.Ph.

(507) 255-5732

Wieruszewski.Patrick@mayo.edu

More information

Publications

Publications are currently not available
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CLS-20581236

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