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Prescription opioids, brain structure, and cognition in older adults with chronic pain

Overview

About this study

The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Older adults (>65 years) with chronic pain nearly every day for at least 3 months due to osteoarthritis of the knee, hip, or shoulder

Exclusion Criteria:

  • Severe mental illness
  • Pre-existing cognitive impairment
  • Life expectancy <12 months
  • Contraindications to MRI
  • Recent opioid use within the past 6 months
  • Previous opioid intolerance, and those at high-risk for opioid-related adverse effects

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/312024. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Nafisseh Warner, M.D.

Contact us for the latest status

Contact information:

Nafisseh Warner M.D.

(507) 266-9670

Warner.Nafisseh@mayo.edu

More information

Publications

Publications are currently not available

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CLS-20581639

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