Clinical Trials

Inclusion Criteria:

• Nondiabetic subjects in whom genotype at rs7903146 is known as we have done previously for our work with TCF7L2.
• Previously participated in our studies of TCF7L2
• Age span of 25-70 years
• No history of diabetes
• Reside within a 100-mile radius of Mayo Clinic, Rochester, MN

Exclusion Criteria :

• Age < 25 or > 70 years (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
• CT genotype at rs7903146
• HbA1c ³ 6.5%
• Use of any glucose-lowering agents including metformin or sulfonylureas.
• For female subjects: positive pregnancy test at the time of enrollment or study.
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.