Clinical Trials

The Primary Objective of this study: -To assess the effects of SAR407899 on coronary vasomotor function using the coronary flow reserve (CFR) in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective percutaneous coronary intervention (PCI). The Secondary Objectives of this study are: - To assess the effects of SAR407899 on quality of life using Seattle Angina Questionnaire physical limitation domain (SAQ-PL) in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective PCI. - To assess the safety of SAR407899 in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective PCI ...

This clinical trial will explore the safety and effect of GCSF-mobilized autologous ex vivo selected CD34 cells for the treatment of CMD in adults currently experiencing angina and with no obstructive coronary artery disease. Eligible subjects will receive a single intracoronary infusion of CLBS16.

The primary purpose of this trial is to determine the safety of XC001 (AdVEGFXC1) in patients who suffer from angina caused by coronary artery disease and have no other treatment options. Subjects in this study will receive one of four intramyocardial doses of XC001 that expresses human vascular endothelial growth factor (VEGF) which induces therapeutic angiogenesis (revascularization).

This study will evaluate the efficacy of ranolazine as compared with placebo when used as part of standard medical therapy in chronic angina subjects with incomplete revascularization post-PCI on the composite of ischemia-driven revascularization or ischemia-driven hospitalization without revascularization.

The purpose of the study is to assess the safety and effectiveness of targeted delivery of Auto-CD34+ stem cells into heart muscle tissue to increase exercise time and decrease anginal symptoms in patients who have angina resistant to treatment and chronic heart muscle death.

The purpose of this study is to perform an in-depth review of pre-operative considerations and indications for spinal cord stimulation (SCS) for refractory angina pectoris (RAP), intraoperative findings, and postoperative reports of any adverse events and (secondarily) patient reports of effectiveness with this therapy.

The purpose of this study is to demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardial ischemia in the distribution of the left coronary artery and who are deemed unsuitable for revascularization.

The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

The purpose of this study is to measure overall activity (sedentary-to-high intensity) during rehab and at 1 year follow-up.  

The objectives of this study are to measure psychosocial cardiac distress* in Latinx/Latino/Hispanic (L/H) women with a history of an acute coronary syndrome (ACS), as well as those with traditional cardiovascular risk factors, but no ACS (diabetes, hypercholesterolemia, obesity, and hypertension), to examine the effects a composite measure for psychosocial cardiac distress has on health-related quality of life (QoL) on women with ACS and those with cardiovascular risk factors and to examine the impact acculturation, acculturative stress, perceived discrimination, and familism can have on the association between cardiac distress and QoL on L/H women with ACS and cardiovascular risk factors. 

*Cardiac distress is defined as ...

The purpose of this study is to evaluate comparisons between a hybrid program of center-based CR which incorporates mHealth remote case management technology (CON+) to a traditional center-based program alone (CON) as well as comparisons between home-based mHealth remote case management alone (HOM+) to a traditional center-based program (CON).

The aim of this project is to assess the feasibility and utility of a virtual world-based cardiac rehabilitation (CR) program as an extension of a face-to-face conventional CR program (Destination Rehab).

The objectives of this study are to examine the prevalence of comorbid sleep disordered breathing (SDB) and insomnia in post-MI patients enrolled in cardiac rehabilitation (CR), to assess whether post-MI CR patients with comorbid SDB and insomnia exhibit a more unfavorable CV profile than those without, and to determine whether post-MI CR patients with comorbid SDB and insomnia show less adherence to CR than those without.