Clinical Trials

The purpose of this study is to develop consensus guidelines and establish baseline outcomes data for various clinical complications and procedural events requiring treatment in the population of patients.

The specific aim of this study is to determine best practice in management of cardiac surgical patients with post- cardiopulmonary bypass (CBP)coagulopathy and bleeding. The aim is to compare outcomes in patients who receive acute normovolemic hemodilution (ANH) blood to control patients with post-CPB factor mediated coagulopathy and clinically significant microvascular bleeding who have did not receive ANH.

The purpose of this study is to directly compare prothrombin complex concentrate to fresh frozen plasma for microvascular bleeding and factor-mediated clotting disorder post cardiopulmonary bypass surgery. 

The purpose of this study is to estimate the proportion of Ventricular Assist Device (VAD) patients with abnormal gastrointestinal bleeding as assessed by HemoQuant fecal occult blood test. Also, in patients with gastrointestinal bleeding present, to summarize the extent of gastrointestinal bleeding; to examine the behavior of HemoQuant fecal occult blood test over time by estimating the proportion of VAD patients with a positive test prior to implantation; at one week, one month, three months, six months and one year post implantation, and after explantation of the VAD and to evaluate whether presence of any abnormal fecal HemoQuant test is ...

The purpose of this study is to learn more about how individual women metabolize and respond to specific medications such as Naproxen and other NSAIDS. The way individuals metabolize NSAIDS may have a relationship to the effectiveness of Naproxen when used for treatment of heavy menstrual bleeding.

The purpose of this study is to monitor and better understand the health issues of people with bleeding disorders.

The primary objectives of this study are to obtain serological bone turnover markers and bone mineral density (BMD) measurements from hemophilia A and von Willebrand disease (VWD) patients aged  ≥ 6 to ≤ 25 years, to compare BMD measurements by HRpQCT and DXA with respect to severity of hemophilia A (mild, moderate, severe) and vWD, annualized bleeding rates, activity and joint scores, and to identify multivariate predictors (correlates) of BMD measurements, including serological bone turnover markers, biochemical and hormonal markers, chronological age, Tanner stage, gender, height, weight, BMI, type of bleeding disorder, severity of bleeding disorder, history of inhibitors, and ...

The purpose of this study is evaluate the reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Approximately 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require urgent ticagrelor reversal will be eligible for enrollment. 

The purpose of this study is to evaluate the safety and tolerability of AK002 in patients with mast cell gastritis and/or gastroenteritis, examine changes in number of mast cells/HPF in gastric and duodenal biopsies, examine any change in gastrointestinal symptom score as estimated by a daily patient-reported outcome (PRO) questionnaire and look for any changes in absolute peripheral blood eosinophil counts.

The purpose of this study is to learn more about aspirin exacerbated respiratory disease (AERD) by collecting blood samples from affected patients to study bleeding and clotting function.

The goal of this study is to establish and maintain a gastrointestinal disease biospecimen bank containing samples of neoplasms, normal tissue, blood and/or any other tissue or cystic fluid from patients undergoing a diagnostic or therapeutic procedure for gastrointestinal disease.