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A Study of Patients with a Positivie Bullous Pemphigoid Disease Test BP180 and BP230 but without a Clinical Diagnosis of Bullous Pemphigoid
Rochester, MN
The purpose of this study is to learn more about bullous pemphigoid disease testings called BP180 and BP230 in patients without a clinical diagnosis of bullous pemphigoid.
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Nomacopan Therapy in Adult Patients With Bullous Pemphigoid Receiving Adjunct Oral Corticosteroid Therapy (ARREST-BP)
Scottsdale/Phoenix, AZ; Jacksonville, FL
The purpose of this two-part study is to confirm the dose of nomacopan for Part A and sample size for Part B, and also rank the order of secondary endpoints for Part B, to evaluate the safety of nomacopan with adjunct OCS in Parts A and B, to test drug effectiveness and particularly whether treatment with nomacopan and adjunct oral corticosteroid (OCS), with steroid tapered (between weeks 2 and 24) according to disease response, leads to a higher proportion of patients in complete disease remission than treatment with placebo and adjunct OCS, and to examine whether there is a reduction in cumulative OCS use and ...
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid
Scottsdale/Phoenix, AZ
The primary purpose of this study is to demonstrate that Dupilumab is superior to placebo in achieving sustained remission off oral corticosteroids (OCS) in patients with bullous pemphigoid (BP).
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Ixekizumab in the Treatment of Bullous Pemphigoid
Scottsdale/Phoenix, AZ
Recently, Interleukin (IL)-17 has been identified as a key driver of chronic inflammation in Bullous Pemphigoid (BP). Ixekizumab is a recombinant high-affinity fully human monoclonal antibody that targets IL-17A Immunoglobulin gamma-1 (IgG1)/kappa-class. The purpose of this study is to determine the effect of Ixekizumab on BP patients.
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Anti-Bullous Pemphigoid Antibodies in Patients with Neurological Disease
Rochester, MN
The purpose of this study is to learn more about Lewy Body disease and a skin condition called Bullous Pemphigoid.