Clinical Trials

This study aims to provide clinical validation of EyeQuant, a fully automated retinal image analysis system for computation of vascular biomarkers indicative of cognitive disorders, using retinal fundus photographs collected from patients with mild cognitive impairment, Alzheimer’s disease, and vascular dementia. When deployed and commercialized, this system can assist in the identification of these biomarkers to aid in assessing drug/treatment efficacy and screening of the aging population in primary care practices and thus enable the early detection and effective management of patients with neurodegenerative disorders.

The purpose of this study is to measure changes in autonomic nervous system functioning to show the impact of down-regulation techniques under cognitive stress.

In this study, we are comparing the performance of children who did and did not receive anesthesia before their third birthday on tests of cognitive skills such as memory, attention and planning/organization

The purpose of this study is to develop a linguistically and culturally- appropriate adaptation of the memory support system (MSS) for Spanish-speaking Hispanics with subjective memory/cognitive complaints or a diagnosis of mild cognitive impairment (MCI) and their care partners in the U.S.

Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications following cardiac surgery with cardiopulmonary bypass that are thought to associated with inflammation. Some studies have shown that ketamine does decrease these complications when compared with anesthetics that are not commonly used in our cardiac anesthesiology practice. Propofol is another commonly used anesthetic medication which is used for induction of anesthesia. Ketamine has not been compared with propofol for potential to reduce post-operative complications associated with the ...

The purpose of this study is to develop a program for individuals living alone with mild cognitive impairment (MCI).

The purpose of this study is to determine if the use of a distraction apron will decrease the length of hospital stay in patients with dementia or cognitive impairment.

This study is being done to learn more about normal memory and aging, mild memory and thinking problems, Alzheimer's disease and other forms of dementia.

The purpose of this study is to determine if anesthesia after concussion is associated with cognitive dysfunction, and if recent concussion is a patient safety risk in the perioperative period

The main goal of this study is to evaluate whether a certain set of memory and thinking tests that are in English also work in other languages after they are translated. The measures will test your memory, thinking, problem solving, and everyday function abilities.

The purpose of this Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is designed to look at disease progression in individuals with early onset cognitive impairment . Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EO-nonAD) participants,and (3) cognitively normal (CN) control participants.

The purpose of this study is to measure the frequency and severity of posttraumatic stress symptoms, depressive symptoms, anxiety symptoms, and cognitive impairment following dismissal from the ICU and three months later. This study also seeks to identify which of the multiple ICUs at Mayo Clinic yields the highest incidence of post-intensive care syndrome so that a future study designed to provide a therapeutic intervention can be implemented in those areas with the greatest potential.

To further investigate biomarkers in CSF as possible predictors for mild cognitive impairment and dementia