Clinical Trials

The purpose of this study is to identify molecular mechanisms that control the rate of disc-dehydration, the effect of degeneration on surrounding bone and ligaments, and identify agents that can be used to alter the course of the disease.

The overall aim of this project is to study the interaction between white blood cells (inflammation) and disc degeneration.

The purpose of this minimal risk evaluation is to collect data that reports on the clinical outcomes of patients treated with the Rampart Duo device in an instrumented lateral lumbar interbody fusion procedure performed at one or two contiguous levels. Data obtained will be used to support publication and podium opportunities.

The purpose of this study is to compare postsurgical pain control following local infiltration analgesia and bupivacaine HCl with EXPAREL, versus without EXPAREL, in adult subjects undergoing open lumbar spinal fusion surgery. The study will also compare additional effectiveness, safety, and health economic outcomes.

The purpose of this study is to collect adult human blood, cerebrospinal fluid, brain, and spine tissues/fluids at time of surgery in order to conduct future studies of the cellular mechanisms of tissue invasion utilized by brain and spine tumors of the central nervous system (CNS).

The purpose of this study is to evaluate the safety and effectiveness of the investigational treatment compared to the control, and obtain indication expansion for Infuse™ use in one and two level TLIFprocedures.

The primary purpose of this study is to compare postsurgical opioid consumption through 72 hours postsurgery in patients receiving local infiltration analgesia (LIA) with EXPAREL and bupivacaine HCl (EXPAREL group) with that of patients receiving standard of care (SOC) (control group) in adult subjects undergoing posterior lumbar spine surgeries where both groups are receiving a multimodal pain regimen.