Clinical Trials

The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use.  This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector.  We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission.  

The purpose of this study is to analyze if exercise can be an effective noninvasive and low risk treatment option in helping patients with alcohol abuse and/or illicit drug use to avoid or delay relapses or slips.

The purpose of this study is to establish an opioid and multiple addiction (OMA) biobank that creates a comprehensive standard patient phenotype using standardized subjective assessments and objective behavioral measurements for future research. 

The purpose of this pilot project is to identify digital biomarkers associated with opioid withdrawal severity and buprenorphine response (withdrawal relief).  

The purpose of this study is to develop a culturally relevant Facebook intervention for American Indian and Alaska Native (AIAN) women in Minnesota recovering from illicit opioid use. The study will consist of three phases: (1) qualitative interviews, (2) intervention content refinement and a moderator exchange (i.e., bi-directional sharing of knowledge between intervention moderators and trainers), and (3) a beta-testing period. A study-specific Community Advisory Committee (CAC) was formed whose members contributed to the study protocol and will continue to provide guidance and input on the study implementation and dissemination. At the advice of the CAC, a Native Elder woman ...

The purpose of this study is to investigate the facilitators and barriers of adults with a history of cocaine use disorder (CocUD) in sustained remission to participating in a Phase I gene transfer study aimed at reducing the rate of cocaine relapse. 

The purpose of this study is to provide the first descriptive analysis of a long-standing HIMS program implementation.

Chemical dependency among pilots has been a long recognized issue. Since the 1970s, the Human Intervention Motivation Study (HIMS) has strived to helped pilots with alcohol and drug dependency. Using a multidisciplinary team, HIMS supports and monitors aviators during their recovery, with the goal of eventual return to flying under an FAA special issuance.

While there have been limited statistics documenting HIM successes, there is virtually no research examining the actual implementation of HIMS, patient populations, factors leading ...

Impulsivity is a major component of addictive behavior contributing to the initiation and perpetuation of Substance Use Disorders (SUDs). The purpose of this study is to investigate the correlation of self-reported measures of impulsivity, neurocognitive task measures of impulsivity,  with craving intensity, the correlation of neurocognitive task measures of impulsivity, and the association between impulsivity measures and sequence variability in the A2AR gene.