Clinical Trials

Will injection(s) of autologous culture-expanded AMSCs be safe and efficacious for treatment of painful Hip OA, and if so, which dosing regimen is most effective?

The purpose of this study is to develop a research repository (a repository is a database of information) to collect data from patients being treated for hip disorders.

Aim #1: The aim of this research is to examine the results of periacetabular and femoroacetabular osteoplasty procedures in patients with symptomatic non-arthritic hip disease using clinical and radiographic evaluation.

This study is designed to:
-analyze effects of surgical treatment
-improve surgical care and quality of life of patients with hip problems/diseases
-ID predictors of surgical outcomes to identify/improve future treatments
-Collect data, images, from patients undergoing surgical treatment of hip disorders (we will not be collecting social security numbers to send to Washington University).

We will collect both non-invasive hemoglobin and conventional serum hemoglobin labs from patients postoperatively following outpatient total joint arthroplasty to determine how closely the values of these two studies correlate in the outpatient total joint arthroplasty patient population.

The purpose of this study is to assess daily living activity levels of patients before and after total hip replacement, and to correlate these activities of daily living to those usually obtained with disease-specific questionnaires.

The purposes of this study is to isolate RNA from bone tissues from ONFH and osteoarthritis (OA) femoral heads and perform RNA sequencing to measure gene expression.

The purpose of this study is to establish a comparator cohort of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other spondyloarthropathies. We will collect demographic information, historical information about diagnosis and past treatment, and clinical, radiographic, and laboratory data on each patient using standardized data collection forms.  We will also collect blood and synovial tissue samples from each patient.  This will provide data and material for clinical and translational research to address questions related to the fundamental differences between the spondyloarthropathies and inflammatory arthritis relating to the response of bone to chronic inflammation.  We intend to enroll sequential ...

The purpose of this study is to see if the inflammation in early stage arthritis can be cessated by changing synoviocyte-macrophage interactions in a way that macrophages do not get activated.

This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.