Clinical Trials

The purpose of this study is to evaluate the safety and tolerability of VGL101 for the treatment of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP).

The purpose of this study is to compare the sensitivity and specificity of ultra-high field MRI (7 Tesla) to standard 3T MRI for the of characteristic imaging findings in the diagnosis of Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP).

The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy.

The North American Mitochondrial Disease Consortium (NAMDC)maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.

The aim of this investigation is to determine if patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) have elevated serum concentrations of calcitonin gene-related peptide (CGRP) which may be relevant for future therapeutic considerations within this patient population.

The purpose of this study is to describe cerebral and retinal vasoreactivity in patients with cerebral small vessel disease (SVD) vs. healthy control, to describe temporal change of cerebral and retinal vasoreactivity, and to test the effectiveness of cilostazol in slowing the progression of white matter dementia (WMD).

The aim of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida. The Center will collect and store detailed phenotypic information, DNA, and other biofluids on affected subjects with diverse cerebrovascular conditions, including, but not limited to, ischemic stroke, transient ischemic attack (TIA), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), vascular dementia (VAD), anoxic brain injury, unruptured intracranial aneurysm (UIA), cavernous malformation, arteriovenous malformations (AVM), carotid and vertebral arterial dissections, symptomatic and asymptomatic cervical carotid artery atherosclerotic stenosis, non-aneurysmal perimesencephalic subarachnoid hemorrhage (naSAH), cerebral venous thrombosis (CVT), moyamoya disease, fibrosmuscular dysplasia (FMD), non-traumatic, angiography-negative subarachnoid ...