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High-dose Hydroxocobalamin (Vitamin B12a) for Vasopressor Refractory Hypotension Following Cardiopulmonary Bypass
Rochester, MN
The purpose of this study is to demonstrate an improvement in arterial blood pressure and a decrease in vasopressor requirement with administration of B12a in patients with post-cardiotomy vasoplegic syndrome on high-dose vasopressors.
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A Study to Assess Carotid Blood Velocity Using Continuous Wave Doppler during Lower Body Negative Pressure
Rochester, MN
The purpose of this study is to determine the changes in carotid blood flow velocity during graded degrees of hypotension with lower body negative pressure (LBNP) using a portable Doppler developed by Flosonics.
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Expanded Access for LJPC-501
Scottsdale/Phoenix, AZ
The primary objective of the study is to provide access to LJPC-501 for distributive shock patients who remain hypotensive despite receiving fluid and vasopressor therapy.
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A Study to Assess Changes of Heart Function and Aortic Stiffness in Relation to Intra-dialytic Hypotension
Rochester, MN
Our aim is to analyze changes in global and/or regional myocardial mechanics of the left and right ventricle before and after hemodialysis.
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A Study of LJPC-501 in Patients with Catecholamine-Resistant Hypotension
Rochester, MN
The purpose of this study is to assess the effect of LJPC-501 (angiotensin II) on the mean arterial pressure in adult patients with catecholamine-resistant hypotension.
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A Study of the Effect, Safety, and Tolerability of LJPC-501 in Patients with Catecholamine-Resistant Hypotension
Scottsdale/Phoenix, AZ
The purpose of this study is to assess the effect, safety, and tolerability of LJPC-501 (angiotensin II) in adult patients diagnosed with catecholamine-resistant hypotension.
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A Study to Understand Why Laying Down May Influence High Blood Pressure in Patient's with a Disease that Causes Problems with the Autonomic Nervous System
Rochester, MN
The purpose of this research study is to better understand why patients with a disease that causes problems with the autonomic nervous system often have high blood pressure when they lie down. We hope that if we learn more about the cause for this problem, we will be able to treat the problem better in the future.