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Adding Pelvic CT with Calcium Scoring May Help Urologists Make Treatment Plans for Peyronie Disease
Jacksonville, FL
Adding a limited noncontrast pelvis CT with Agatston calcium scoring to evaluate and quantify calcified Peyronie plaques can increase the number of patients that qualify for collagenase Clostridium histolyticum (CCH) injection therapy compared with the qualitative assessment by penile duplex Doppler ultrasound (PDDU) and clinical exam.
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Patient Outcomes after Intralesional Injections of Collagenase Clostridium Histolyticum for Peyronie's Disease
Scottsdale/Phoenix, AZ
The purpose of this study is to review the outcomes and patient characteristics for our institutional experience with the use of Xiaflex®.
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Effect of Xiaflex Injection on Erectile Function in Peyronie’s Disease Patients
Rochester, MN
Peyronie’s disease is a connective tissue disorder that causes fibrosis of the tunica albuginea. It is most commonly characterized by penile curvature while erect, penile pain, and erectile dysfunction. Collagenase clostridium histolyticum (XIAFLEX) is a injectable therapy that is FDA approved for the treatment of Peyronie’s disease. The goal of this study is to evaluate and report on treatment-associated outcomes in patients with a diagnosis of Peyronie’s disease.
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Efficacy of Penile Traction Therapy Using a Novel Device
Rochester, MN; Rochester, MN
This clinical trial is designed to assess the safety, dosing, and preliminary efficacy of a novel penile traction device on correcting deformities relating to Peyronie's disease, a condition which results in penile curvature and length loss. The trial is designed as a randomized, placebo-controlled study with men randomized to receiving no therapy or penile traction therapy 30 minutes once, twice, or three times daily. The study will occur over a 3 month period, after which an open label phase for 3 months will be conducted. Final assessments for adverse effects will also be assessed at 9 months.
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A Study of Genetic Profiling of Peyronie's Disease Patients
Rochester, MN
The purpose of this study is to provide comprehensive genetic profiling of Peyronie's Disease (PD) patients, discover candidate genes associated with the disease, and to compare the identified candidate genetic mutations/variations with familial and non-familial cases.
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A Study to Create a Research Database by Gathering Information about Peyronie’s Disease and the Effects it has on Erectile Dysfunction
Jacksonville, FL
The purpose of this investigation is to develop and maintain a database for patients with PD +/- ED in the five years preceding the introduction of collagenase histolyticum (2008-2013) in comparison to the five years following Xiaflex FDA approval (2013-2018).