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PLS Natural History Study
Jacksonville, FL; Rochester, MN
The purpose of this study is to develop a natural history dataset and biorepository of early Primary Lateral Sclerosis (PLS) and well-established PLS cases for future clinical trials.
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Development of a PLS-Specific Clinical Rating Scale, Capable of Evaluating the Clinical Functional State of Patients with PLS in Multi-Site Study
Jacksonville, FL; Rochester, MN
The purpose of this study is to assess the internal consistency and construct validity of the scale, assess test-retest reliability, intra-rater reliability, inter-rater reliability, reliability between in-person and telephone administration of the scale, to determine the sensitivity of the scale to detect changes over time.
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A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.
No Locations
The COMMEND Study will assess the safety and effectiveness of FLX-787 in men and women with Motor Neuron Disease [including Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS) or Progressive Muscular Atrophy (PMA)] experiencing muscle cramps. Participants will be asked to take two study products during the course of the study. One of these study products will be a placebo. Approximately 120 participants in approximately 30 study centers across the United States are expected to take part. Participants will be in the study for approximately 3 months and visit the study clinic 3 times.
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A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps
Scottsdale/Phoenix, AZ
The COMMEND Study will assess the safety and effectiveness of FLX-787 in men and women with Motor Neuron Disease [including Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS) or Progressive Muscular Atrophy (PMA)] experiencing muscle cramps. Participants will be asked to take two study products during the course of the study. One of these study products will be a placebo. Approximately 120 participants in approximately 30 study centers across the United States are expected to take part. Participants will be in the study for approximately 3 months and visit the study clinic 3 times.