Clinical Trials

The purpose of this study is to determine the impact of opioid administration on diaphragm muscle forces during resting breathing and during higher force maneuvers by using a non-invasive shear wave elastography (SWE) method.

The purpose of this study is to develop, in close collaboration with stakeholders, an evidence-based decision aid for patients with acute respiratory failure.  To evaluate the impact of the decision aid on patient-important outcomes. We will conduct a prospective trial assessing the impact of the decision aid (vs. usual specialist care) on patient knowledge, patient involvement in decision-making, decision quality, treatment choice, and patient outcomes.

The purpose of this study is to assess the feasibility, reliability and validity of oxygen supplementation duration as an intermediate outcome of resolution of acute hypoxic respiratory failure from all cause in comparison with PaO2/FiO2, SaO2/FiO2 ratio, and lung injury score trajectories in critically ill patients with acute respiratory failure.

The purpose of this study is to investigate the association of decreased minute ventilation and greater incidence of oxygen arterial desaturation, hypercapneic or hypoxemic respiratory failure that requires high flow nasal oxygen therapy, non-invasive ventilation or re-intubation following cardiothoracic surgical procedures.
 

The purpose of this study is to investigate the effectiveness of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the effectiveness of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.

The purpose of this study is to establish the effectiveness of a combination of an inhaled corticosteroid and a beta agonist compared to placebo for the prevention of acute respiratory failure (ARF) in hospitalized patients with pneumonia and hypoxemia.

Severe acute respiratory failure requiring prolonged mechanical ventilation is the most common form of acute organ dysfunction in the hospital, and is often associated with multiple organ failure, high mortality, and functional impairment. The purpose of this study is to improve the outcomes of patients at high risk with early intervention using an electronic medical records checklist aimed at preventing the lung injury that commonly leads to organ failure.

The primary purpose of this study is to evaluate whether early treatment with therapeutic hypothermia (TH), along with neuromuscular blockade (NMB) to prevent shivering, will be beneficial to patients with Acute Respiratory Distress Syndrome (ARDS).

The purpose of this study is to evaluate the use of a non-invasive bedside echocardiography to assess the effect of mechanical ventilation (invasive and non-invasive) on the function of the heart.

The purpose of this study is to deepen our understanding of the ARDS mechanism following transplantation through an analysis of cytokines, metabolomics and proteomics before ARDS occurs, and during the early phase of ARDS development.

The purpose of this trial is to compare the effectiveness of psychological support based on positive suggestions (PSBPS) vs. usual care on mental health morbidity and cognitive function in survivors of critical illness.

The purpose of this study is to compare a standard steroid dosing algorithm to a novel biomarker-tailored steroid dosing algorithm for patients receiving corticosteroids for community acquired pneumonia.  Patients with severe community acquired pneumonia may benefit from adjunctive corticosteroid therapy. The optimal patient selection, dosing and duration of steroids is unknown.

The primary purpose of this study is to determine if the reduction in TMPRSS2 activity via direct inhibition with Camostat mesilate combined with standard of care (SOC) treatment will increase the proportion of patients alive and free from respiratory failure at Day 28 in SARS-CoV-2 as compared to SOC treatment with placebo.