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Transcatheter Pulmonary Valve Replacement and Catheter Ablation of Ventricular Tachycardia in Tetralogy of Fallot
Jacksonville, FL; Rochester, MN
The aim of this study is to determine the outcomes of catheter ablation before transcatheter PVR among patients with Tetralogy of Fallot (TOF, a specific type of congenital heart defect). It is hypothesized that a combination of successful catheter ablation and transcatheter PVR placement will result in a reduction in a conventional risk score calculation (and consequently, fewer patients meeting criteria for primary prevention ICD placement) owing to a combination of VT circuit elimination and favorable RV remodeling.
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Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot
Rochester, MN
The purpose of this study is to explain the functional change mechanism linking right atrial (RA) hypertension, right heart (RH) remodeling and onset of symptoms such as arrhythmias and impaired aerobic capacity, since symptomatic status is a risk factor for mortality in the Tetralogy of Fallot (TOF) population.
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A Study to Evaluate Sacubitril-Valsartan for Left Ventricular Reverse Remodeling in Adults with Congenital Heart Abnormality
Rochester, MN
The purpose of this study is to determine the optimal medical therapy to improve left ventricular (LV) function. Improvement in LV function has the potential to reduce the burden of heart failure and improve clinical outcomes in the Tetralogy of Fallot (TOF) population.
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A Study to Assess the Role of Biomarkers in Risk Stratification in Adults with Congenital Heart Disease
Rochester, MN
The purporse of this study is to determine if biomarker assay obtained at baseline can predict future risk of cardiovascular adverse events, and to determine if temporal changes in biomarker levels can provide a better risk prediction compared to biomarker assay obtained at baseline.
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A Study to Evaluate Aortic Dilatation in Patients with Conotruncal Abnormalities
Rochester, MN
The purpose of this study is to assess operative and postoperative outcomes after aortic valve surgery, evaluate for changes in ascending aorta diameter by comparing pre-operative CT imaging to measurements on follow-up imaging, and examine late outcomes and functional status during the follow-up period with specific focus on mortality, need for re-operation and incidence of aortic dissection.
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Exercise during Heart Cath in CHD Patients
Rochester, MN
The purpose of this study is to compare the difference in the ability to detect blood flow abnormalities between invasive assessments performed at rest versus exercise.
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Stress Echo 2030
Rochester, MN
This study (SE2030) will establish a platform of data to build the perfect stress echo test, suitable for all patients, anywhere, anytime, also quantitative and operator independent.