Ryan T. Hurt, M.D., Ph.D.

The purpose of this study is to test if senescent cells and their secretome contribute to Long-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectively eliminate senescent cells, should be initiated. 

The purpose of this study is to create a biobank of specimens from healthy individuals that are being seen in the newly formed Healthy Longevity Clinic at Mayo Clinic.  We hope to use the samples collected to assist in improving future care that may impact scientific excellence.

The purpose of this study is to gather information on the effectiveness of low-level laser therapy (LLLT) in combination with clinical patient education manuals to reduce neck and shoulder pain.   

The purpose of this study is to address and improve exercise intolerance and post-exertional malaise (PEM) as manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). 

This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and community settings where it can be integrated into COVID-19 programs and subsequent treatment plans.

This protocol describes a prospective, multi-center, multi-arm, double-blind, randomized, controlled, platform trial, with different interventions organized as appendices to the protocol. Each appendix evaluates potential mechanisms of action, efficacy, and safety of antivirals and other therapeutics in individuals with PASC, according to the platform protocol objectives. The hypothesis is that persistent viral infection and/or overactive/chronic immune response and inflammation are underlying contributors to PASC and that antiviral and other applicable therapies may result in viral clearance or decreased inflammation and improvement in PASC symptoms.

The purpose of this study is to better understand the effects of oral nicotinamide riboside (NR) on systemic vascular perfusion in a cohort of healthy adults.

The purpose of this study is to test if Variable Pulse TMS (Transcranial Magnetic Stimulation) can result in objective improvements in patients with Post COVID Syndrome (PCS).

The purpose of this study is to determine if glepaglutide is a safe treatment for participants with Short Bowel Syndrome (SBS), as well as how well effectiveness is maintained during long term treatment.  

The primary purpose of this trial is to confirm the effectiveness of glepaglutide in reducing parenteral support volume in patients with short bowel syndrome. Glepaglutide is the International Nonproprietary Name and USAN for ZP1848.

The purpose of this study is to establish whether patients with post-COVID syndrome have different serologic markers than control patients who have had COVID and recovered without progression to post-COVID syndrome.

The purpose of this study will be looking at the feasibility of using AI to generate individualized responses to predictable pragmatic patient queries by reviewing select data points of the patient's medical history.  The research study is a review of patient data collected in the medical record, and patient questions to physicians; then comparison of responses by physicians and  AI generated responses.

Compliance is the biggest challenge in patients with Short Bowel Syndrome (SBS) on Home Parenteral Nutrition. These patients need to hydrate themselves to meet the excess fluid loss due to their anatomy. Oral Rehydration Solution (ORS) is prescribed to all these patients. The investigators believe that taste of the standard ORS is the biggest reason why these patients are not compliant. The new ORS in the market has been prepared with this in mind. The investigators want to study if this new ORS will improve the compliance in this patient cohort.

The purpose of this study is to determine if employees will use under desk foot pedal elliptical devices at their workstation to increase their level of physical activity.

The purpose of this study is to compare the incidence and frequency of elevated liver enzymes or parenteral (IV) nutrition-associated liver disease, in adult patients who are receiving daily versus three time per week soybean based intravenus (IV) fat emulsions.

The purpose of this study is to investigate the fecal microbiome composition of HLC patients when compared to benchmark controls.

The purpose of this study is to establish a registry that will follow patients that are seen in the PCCOC clinic with Post-COVID symptoms that persist for greater than 28 days. 

This study will be a retrospective and prospective analysis of patients with Post-COVID-19 symptoms that persist for greater than 28 days that are seen in the PCoCC (Post COVID Care Clinic), CARP, Pulmonary for post COVID clinic, Neurology,  or approval by the MAGPIES research group. 

Data for the registry will be aggregated from the EHR and by questionnaires. This data can be used to better guide strategic and tactical decisions as clinicians and healthcare managers respond to the rapidly evolving Post-COVID-19 patients.

The biobank will be optional for the participant and is designed to prospectively collect research biospecimens from Post-COVID-19 with symptoms that persist for greater than 28 days. 

Novel, high-performance genomic technologies now allow detection of signals from cancers in the blood, giving rise to a new paradigm of multi-cancer detection (MCD) tests. Blood is inherently well suited for detection of cancer biomarkers as it contains circulating tumor cells and tumor cell-free DNA (cfDNA) that have been “shed” from an occult asymptomatic developing cancer. MCD tests analyze these genomic features of the circulating DNA, distinguish it from background signals and determine a site of tumor origin to guide subsequent testing to establish a firm cancer diagnosis (hopefully pre-symptomatic early stage and highly curable). An effective MCD test should have three features: a reasonably high aggregate sensitivity, coverage of a wide range of tumor types and a very low false-positive rate. There are currently multiple companies with MCD tests in production.

This study proposes a prospective observational registry study involving patients who have undergone clinical MCD testing at Mayo Clinic or referred to Mayo Clinic with MCD test results for further evaluations and management.

The purpose of this study is to evaluate the impact of vagal nerve stimulation on symptom burden, neuroinflammatory change, and blood markers of inflammation in patients with post COVID syndrome who have fatigue and headache.

This study is being implemented to identify the role of prophylactic use of ethanol lock in adult patients on home parenteral nutrition (HPN). Central catheter related blood stream infection is a major complication in patients on HPN. The investigators hypothesize that the prophylactic use of ELT will decrease the number of catheter related blood stream infections compared to the control group. The investigators further hypothesize that with the introduction of prophylactic ELT, the number of infections will decrease. This will improve the quality of life (assessed using Questionnaire) in HPN patients.

With, one in three Americans now having a body mass index (BMI) greater than 30, and the fastest growing segment of the population having a BMI greater than 40, it is paramount to conduct validation of approaches to measure body composition. Currently the dual-energy x-ray absorptiometry (iDXA) is the gold standard for measuring the body composition. But it is often difficult to perform since it is limited to specific height, weight and BMI's. InBody is a tool which uses bio electric impedance to measure the body composition. This study will compare both approaches. Validation is necessary as it is clinically quite pertinent to accurately assess a patients' body fat percentage, fat free mass, and total body water and changes that are occurring with nutritional support.

The purpose of this study is to remotely use the Ellipsis Health (EH) voice analysis technology to record the speech patterns and content of individuals with a recent diagnosis of Coronavirus-19 (COVID-19) presenting to the post-COVID-19 clinic at Mayo Clinic, to validate its use as a tool to screen for major depressive disorder (MDD) and generalized anxiety disorder (GAD) against gold-standard questionnaires used in clinical practice namely the PHQ-9 and GAD-7