Faculty

Michael J. Krowka, M.D.

Clinical Studies

Pulmonary Vascular Complications of Liver Disease 3 (PVCLD3) Rochester, Minn.
The purpose of this study is toexamine whether increased sphingosine 1 phosphate : ceramide ratio and circulating bile acids are associated with HPS in patients with advanced liver disease.

Pulmonary Vascular Complications of Liver Disease-2 (PVCLD2) (PVCLD2) Rochester, Minn.
The purpose of this study is to determine if certain genes, hormones, or other factors predict the risk of developing lung vessel disease in patients with liver disease and whether they determine outcome.
Sorafenib in Patients With Hepatopulmonary Syndrome: A Double-Blind Randomized Clinical Trial (SHPS) Rochester, Minn., Scottsdale/Phoenix, Ariz.
The main purpose of this clinical trial is to determine the safety and effects of the study drug, sorafenib, in adults diagnosed with hepatopulmonary syndrome (HPS). The study will evaluate how well the drug is tolerated and its effect on the level of oxygen in the blood and the function of the lung vessels.
United States CTEPH Registry Rochester, Minn.
The purpose of this registry will be to promote a greater understanding of the prevalence, pathophysiology, evaluation, and treatment of United States patients with chronic thromboembolic pulmonary hypertension through shared information, education, and collaborative investigation among pulmonary hypertension centers throughout the U.S.