Pankaj J. Pasricha, M.B.B.S., M.D.

The purpose of this study is to evaluate cutaneous nerve biopsies from patients with refractory gastrointestinal motility disorders, and to evaluate skin biopsies for signs of small fiber neuropathy in GI dysmotility patients, which may provide a better understanding of the underlying pathology of their condition.

The purpose of this study is to identify novel anti neuronal antibodies that contribute to autoimmune gastrointestinal motility disorders by analyzing the serum of patients with abnormal gastrointestinal motility.

The purpose of this study is to create a research resource of GI motility patients with symptoms referable to JAG-A syndrome (Joint hypermobility, Autonomic dysfunction, Gastrointestinal dysmotility – Autoimmune type).

The purpose of this study is to observe patients with symptoms of(Gp) and (FD).

The primary aim of this pilot and feasibility, hypothesis-generating study therefore is to evaluate the effect of peroral endoscopic pyloromyotomy (G-POEM) vs. sham endoscopic surgery on symptoms in patients with diabetic or idiopathic gastroparesis.

Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support. There are few effective treatments available; more recently, a procedure called G-POEM (gastric peroral endoscopic myotomy) has been advocated to relieve symptoms by improving gastric emptying; however, it is not clear whether this is safe or effective.