Sundeep Khosla, M.D.

The purpose of this study is to test if a rare variant in the osteocalcin protein may act as a gain of function mutation in this molecule.

The purpose of this study is to assess key characteristics of bone quality, specifically material strength and porosity, in patients who have type 2 diabetes. These patients are at an unexplained increased risk for fractures and there is an urgent need to refine clinical assessment for this risk.

The purpose of this study is to monitor short term changes in bone microarchitecture, with the initiation of cross sex hormone therapy in transgender men and transgender women – during this time, there is a large flux in hormonal status.

The purpose of this study is to evaluate whether atenolol is effective and safe for the prevention of bone loss in postmenopausal women.

This study is designed to answer the question as to whether the sympathetic nervous system is an important determinant of bone metabolism in humans.

This protocol addresses three main questions. How are gene expression changes in bone cells affected by aging?  Is aging associated with decreased signaling between bone cells? How does treatment with the osteoporosis medication denosumab affect bone cell signaling?

The purpose of this study is to identify new mechanisms responsible for age related impairment in bone formation by studying specific genes and pathways related to bone formation.  

The purpose of this study is understanding changes in bone across a variety of conditions, including normal processes (such as skeletal changes that occur with aging), in pathologic conditions (such as in patients with diabetes), or in response to therapeutic interventions (such as in patients treated with teriparatide – a skeletal anabolic agent used clinically).

The purpose of this study is to obtain bone from up to 200 patients undergoing orthopedic procedures (including elective hip replacement or hip replacement following fracture) to perform these studies.  From these waste bone samples that would otherwise be discarded following review by pathology, we will isolate bone cells (osteoblasts, osteoclast, and osteocytes), protein, RNA, and DNA.  

The purpose of this study is to test the hypothesis that patients with T2DM will have greater deterioration in BMSi and in cortical porosity over 3 yrs as compared to sex- and age-matched non-diabetic controls; and identify the circulating hormonal (e.g., estradiol [E2], testosterone [T]) and biochemical (e.g., bone turnover markers, AGEs) determinants of changes in these key parameters of bone quality, and evaluate the possible relationship between existing diabetic complications and skeletal deterioration over time in the T2DM patients.

The purpose of this study is to find differences in the bone thickness and structure of racial minorities compared to whites, who have already been studied

The purpose of this study is to test whether markers of cellular aging and the SASP are elevated in subjects with obesity and further increased in patients with obesity and Type 2 Diabetes Mellitus (T2DM) and to relate markers of cellular aging (senescence) and the SASP to skeletal parameters (DXA, HRpQCT, bone turnover markers) in each of these groups.

The purpose of this study is to test whether intermittent senolytic therapy reduces markers of biological age and improves bone turnover markers and skeletal parameters in older postmenopausal women.