Mohamad H. Yamani, M.D.

Closed for Enrollment

• A Long-Term Safety Extension Study of Mavacamten (MYK-461) in Adults With Hypertrophic Cardiomyopathy Who Have Completed the MAVERICK-HCM (MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE) Jacksonville, Fla.

  The primary purpose of this study is to assess the long-term safety and tolerability of mavacamten in participants with Hypertrophic Cardiomyopathy (HCM) previously enrolled in 1 of 2 placebo-controlled trials: MAVERICK-HCM for Non-obstructive (nHCM) and EXPLORER-HCM for Obstructive (oHCM).

• A Randomized Study of the Effectiveness of an Integrated Tele-monitoring and Patient-centric Health Coaching Strategy (Tele-HC) in Adult Patients Recently Hospitalized With Acute Decompensated Heart Failure (ADHF) Compared to Standard Care (Tele-HC) Jacksonville, Fla., La Crosse, Wis., Eau Claire, Wis.

  This study evaluates the effectiveness of remote tele-monitoring and health coaching in helping to reduce hospitalizations in heart failure patients. Half of participants will receive tele-monitoring and health coaching, while the other half will receive standard health care provided by their chosen provider.

• A Randomized, Double Blind, Placebo Controlled Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy ((EXPLORER-HCM)) Scottsdale/Phoenix, Ariz., Jacksonville, Fla.

  This is a multicenter, international, double-blind study of the administration of mavacamten in participants with symptomatic obstructive HCM (oHCM). Approximately 220 participants will be randomized to receive placebo or mavacamten.

• INcrease Of VAgal TonE in CHF (INOVATE-HF) - A Randomized Study to Establish the Safety and Efficacy of CardioFit for the Treatment of Subjects With Heart Failure and Left Ventricular Dysfunction (INOVATE-HF) Jacksonville, Fla.

  The purpose of the INOVATE-HF study is to demonstrate the long-term safety and efficacy of vagus nerve stimulation with the CardioFit system for the treatment of subjects with Heart Failure.