Michael J. Brown, M.D.

Closed for Enrollment

• Perioperative HMG-CoA-Reductase-Inhibitors: A Pilot Study Assessing the Role of “Statin” Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery Rochester, Minn.

  The purpose of the present study is to quantify the degree of modulation, if any, in the perioperative inflammatory response associated with statins use. Specifically, we hypothesize that:

  In a population of patients undergoing elective orthopedic spine surgery, administration of a specific statin (Simvastatin, Zocor®, Merck Pharmaceuticals), will be associated with a decrease in perioperative inflammatory markers when compared to patients not taking statins