Faculty

Patricio Escalante, M.D., M.S.

Clinical Studies

Systems biology to predict progression and treatment response in Mycobacterium avium complex (MAC) pulmonary infections Rochester, Minn., Jacksonville, Fla.
The purpose of this study is to develop two quantitative risk scores for MAC-PD that computationally integrates clinical, immunological, and pharmacological data.

Immunodiagnosis of Tuberculosis Infection with Flow Cytometry Rochester, Minn.
The purpose of this study is to compare the diagnostic accuracy and potential predictive value of tuberculin skin test (TST) and interferon-g release assays (IGRAs) with FCA, multiplexed cytokine and chemokine profiling (MCCP), RNA transcriptional signatures (RTS) testing for latent tuberculosis infection (LTBI) in patients with and without immunosuppression.

A Phase 2/3, Randomized, Double-blind, Placebo-controlled, Multicenter, Prospective Study to Assess the Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole in Patients With Treatment-refractory Mycobacterium Avium Complex Lung Disease (MACrO2) Rochester, Minn.
The purpose of this study is to assess epetraborole + OBR (Optimized Background Regimen) versus placebo + OBR in patients with treatment-refractory MAC lung disease.
Assessing Blood Volume Impact on QuantiFERON Test Accuracy Rochester, Minn.
The purpose of this study is to evaluate whether the volume of whole blood collected in QuantiFERON testing tubes impacts the accuracy of test results.
Effect of estradiol in the Immunopathology of MAC infection Rochester, Minn.
The purpose of this study to assess the effect of estrogen on monocyte/macrophage response induced by MAC infection in vitro using murine peritoneal macrophages and human peripheral blood monocytes.