Charles H. Adler, M.D., Ph.D.

Closed for Enrollment

• An Open Label, Multicenter Study, Evaluating the Safety and Efficacy of 18F-AV-133 PET Imaging to Identify Subjects with Dopaminergic Degeneration Among Subjects Presenting to a Movement Disorders Specialty Clinic with an Uncertain Diagnosis Scottsdale/Phoenix, Ariz.

  The purpose of this study is to determine whether 18F-AV-133 PET scans can be used to differentiate subjects with Parkinson's Disease from other movement disorders.

• Diagnostics, Imaging and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project (DIAGNOSE-CTE) Scottsdale/Phoenix, Ariz.

  The purpose of this study is to collect and analyze neuroimaging, genetic markers, and clinical presentations and progressions of chronic traumatic encephalopathy to develop methods of diagnosing the disease during life. 

   

   

   

• Golfer's Cramp: Correlation of Wrist Movements and Surface EMG with Putter Movements Scottsdale/Phoenix, Ariz.

  The investigators will investigate golfers with visual evidence of an involuntary movement while putting before and after treatment with a low dose of propranolol.

• Systemic Synuclein Sampling Study (S4) (S4) Scottsdale/Phoenix, Ariz.

  The purpose of this study is to measure alpha-synuclein in peripheral body tissues and fluids in Parkinson's disease (PD). This may help in developing better treatments for PD patients in the future.

• Transcutaneous Submandibular Gland Biopsy: Feasibility of Repeat Biopsy as a Progression Marker for Parkinson&Apos;s Disease Scottsdale/Phoenix, Ariz.

  The purpose of this study is to perform biopsies of one of the glands that make saliva. The biopsied tissue will then be analyzed to see if it has changes that occur in Parkinson's disease. This study will determine whether it is possible to do a second biopsy a few years after a previous biopsy and determine whether there are changes in the biopsy that would allow for analysis of disease progression.